What is Deuterium?
In nature hydrogen exists in three varieties: hydrogen (H) with a mass number of one, deuterium (D) with a mass number of two and tritium (T) with a mass number of three. D is a stable and non-radiating isotope of hydrogen. It has been well-known for decades that due to their mass difference, H and D behave differently in chemical reactions. In other words, D can be considered as an independent element. When D was applied in great concentrations, D exerted a major impact on various biological systems (viruses, algae, plants, mice, etc.) which is the consequence of the so called isotopic effect.
In view of the water content of living organisms and the D2O concentration of natural waters (0.015 atom%) the D concentration in the living organisms is more than 10 mM/L. Just to put this figure in perspective it should be noted that the Ca2+ concentration in human blood is approx. 2 mM/L. It means that up to now modern science ignored an element, which is present in five times higher concentration than calcium.
In the early 1990s, it has been discovered, that decreasing the deuterium (heavy isotope of hydrogen) concentration of the body below normal physiological level, it delays the progression of several types of cancer in mice and prolongs their survival [Somlyai et al., FEBS Lett. (1993) 317, 1-4]. Depletion of body deuterium (D) can simply be achieved by consumption or prolonged administration of deuterium-depleted water (DDW) and nutrients deficient in D. It was therefore postulated that D-depletion would have therapeutic use in patients with cancer and other neoplastic diseases. In subsequent toxicology studies DDW appeared to be completely safe and non-toxic when given to mice in place of regular water for several months. Following preclinical safety and efficacy studies, a Phase II double blind randomized clinical trial was initiated to evaluate the potential usefulness of therapeutic efficacy and safety of DDW in patients with prostate tumor. It was recognized that the shortage of deuterium can cause a significant change in cell processes, that followed. The most important outcome of the research carried out with DDW was that several independent experiments supported the findings that the tumorous cells are extremely sensitive to the withdrawal of D. There is conclusive evidence that the application of DDW causes a delay of cell growth of tumors in tissue culture. In animal experiments, DDW slowed down, halted or reversed the growth of tumors originating from malignant (neoplastic) cell lines of human origin, in immunosuppressed mice and spontenous tumors of cats and dogs. The molecular mechanism of the anticancer activity of deuterium depletion is not fully understood. Recent results show that depletion of deuterium induces changes in the expression of genes, which play an already recognized role in the pathology of most cancer types [Gyöngyi and Somlyai, In vivo (2000) 14:437-440].
Clinical Study Results
The results also revealed that the healthy cells have a high capacity to tolerate the decrease of D concentration. This is the basis of the findings; that the cells harbouring several mutations in the chromosomes resulting in a very different metabolism and uncontrolled growth are more sensitive to D-depletion. This is the basis of the selectivity which can lead to cell necrosis; resulting regression of the tumor without evoking any serious side effects on healthy cells. Deuterium depletion opens new perspectives in cancer treatment and prevention offering a completely safe and non-invasive treatment modality. Deuterium depletion has opened a highly original and promising new approach to the prophylaxis and treatment of a wide range of tumor diseases.
Book: Defeating Cancer!
The Biological Effect of Deuterium Depletion by Gábor Somlyai
The 1st International Symposium on Deuterium Depletion
13-14 May 2010 in Budapest, Hungary